Preimplantation Genetic Diagnosis (PGD) India

Preimplantation genetic diagnosis (PGD) is being used increasingly at the Fertility Institutes to dramatically improve the chance of a successful IVF pregnancy in couples where prior IVF failures have remained unexplained. It has been estimated that over half of all IVF failures are not able to be explained by an apparent problem with embryo “quality”. For many couples however, this statistic is quite misleading. Most IVF centers look very closely at the appearance of embryos under the microscope as they attempt to determine a “good” or “high quality” embryo from those of lesser quality…

IVF Success Following PGD

Single cycle IVF success rates (the chance of becoming pregnant)in our program can be raised significantly* when 2 or 3 embryos known to be chromosomally normal are transferred. The chance of healthy pregnancy may double when known genetically normal embryos are utilized. Implantation rates (the chance of each single embryo becoming a gestation) can also be raised greatly with PGD. To determine whether these embryos are chromosomally normal, a PGD analysis is carried out by our scientists prior to their selection for transfer to the mother. In an genetically normal embryo, there should be 2 (and only 2) chromosomes of each of 22 chromosome types in addition to one set of XX female or one set of the XY male chromosomes….

The Successful Use of PGD for Recurrent IVF Failure

Most couples presenting to us for consideration of PGD have one of the following conditions : -

Prior unexplained IVF failure Recurrent miscarriages Maternal age over 38 Conception of a chromosomally abnormal child or fetus Polycystic ovary syndrome History of ovarian hyperstimulation syndrome Heritable medical condition in either the patient or in a prior child (such as hemophilia)

                                        And many more…

The Accuracy Of PGD In “Genetic” IVF Failure

The accuracy of PGD in determining genetic abnormalities exceeds 98%. Once we have the genetic information about each embryo available, we are able to sit down with each couple prior to the embryo transfer, discuss the genetic health of each embryo, explain how the genetic information has improved the chances for pregnancy success compared to their prior unsuccessful attempts at IVF elsewhere, and make a determination about the return of the now “known to be normal” embryos to the mother to be….

The Success Of PGD In Improving Recurrent IVF Failure

Using PGD to select the best embryos is clearly superior to traditional methods of selection. Miscarriage rates following PGD are far less than with standard IVF. Currently more than half of couples with two or more normal embryos and maternal age under 41 will take home a baby on a first IVF-PGD attempt in our program. And these are in couples who have failed multiple prior IVF attempts elsewhere!…

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Ovulation Induction

Ovulation induction is a form of treatment which involves stimulation of the ovaries to bring about development of a ripened egg which can then be fertilised by a normal act of intercourse. Ovulation induction is used to treat women who do not ovulate or who ovulate irregularly. Ovulation induction can be used for women who have been diagnosed with Hypothatic Pituitary failure or women with Polycystic Ovarian Syndrome (PCO) and consequently may not be ovulating (Annovulatory)….

Medications for Ovulation Induction

The four major types of drug therapy for ovulation problems include Clomid (Serophene, clomiphene citrate), injectable gonadotropins, GnRH pump, and bromocriptine.

These medications include clomiphene citrate. This oral drug promotes growth of the fluid-filled sacks (follicles) containing the eggs. If you do not ovulate, or you ovulate and do not become pregnant after clomiphene therapy, other medications may be prescribed either alone or in combination….

How is induction of ovulation performed in Abroad ?

Ovulation induction, in ovulatory women, is always combined with intrauterine insemination. Ovulation induction should only progress after a complete and thorough evaluation. All underlying hormonal disorders (such as thyroid dysfunction) should be treated prior to resorting to ovulation induction with fertility drugs…

Pregnancy success rates for induction of ovulation

Success rates for induction of ovulation vary considerably and depend on the age of the woman, the type of medication used, whether there are other infertility factors present in the couple, etc..